{"id":23,"date":"2026-06-18T10:10:32","date_gmt":"2026-06-18T08:10:32","guid":{"rendered":"https:\/\/biologistjournal.com\/vi\/2026\/06\/18\/beo-phi-tiet-lo-bi-mat-giua-gen-va-hormone\/"},"modified":"2026-06-18T10:11:34","modified_gmt":"2026-06-18T08:11:34","slug":"beo-phi-tiet-lo-bi-mat-giua-gen-va-hormone","status":"publish","type":"post","link":"https:\/\/biologistjournal.com\/vi\/2026\/06\/18\/beo-phi-tiet-lo-bi-mat-giua-gen-va-hormone\/","title":{"rendered":"B\u00e9o ph\u00ec ti\u1ebft l\u1ed9 b\u00ed m\u1eadt gi\u1eefa gen v\u00e0 hormone"},"content":{"rendered":"

\"B\u00e9o“`html<\/p>\n

B\u00e9o ph\u00ec ti\u1ebft l\u1ed9 b\u00ed m\u1eadt gi\u1eefa gen v\u00e0 hormone<\/h1>\n

B\u00e9o ph\u00ec hi\u1ec7n \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn g\u1ea7n 30% d\u00e2n s\u1ed1 th\u1ebf gi\u1edbi, con s\u1ed1 \u0111\u00e3 t\u0103ng g\u1ea5p ba l\u1ea7n k\u1ec3 t\u1eeb n\u0103m 1975. L\u00e2u nay, b\u1ec7nh n\u00e0y th\u01b0\u1eddng \u0111\u01b0\u1ee3c xem l\u00e0 s\u1ef1 m\u1ea5t c\u00e2n b\u1eb1ng \u0111\u01a1n thu\u1ea7n gi\u1eefa l\u01b0\u1ee3ng calo n\u1ea1p v\u00e0o v\u00e0 ti\u00eau hao. Tuy nhi\u00ean, tr\u00ean th\u1ef1c t\u1ebf, \u0111\u00e2y l\u00e0 m\u1ed9t c\u0103n b\u1ec7nh ph\u1ee9c t\u1ea1p, xu\u1ea5t ph\u00e1t t\u1eeb s\u1ef1 t\u01b0\u01a1ng t\u00e1c ch\u1eb7t ch\u1ebd gi\u1eefa y\u1ebfu t\u1ed1 di truy\u1ec1n, m\u00f4i tr\u01b0\u1eddng v\u00e0 t\u00edn hi\u1ec7u hormone. C\u00e1c c\u01a1 ch\u1ebf \u0111\u1eb1ng sau b\u1ec7nh b\u00e9o ph\u00ec \u0111ang d\u1ea7n \u0111\u01b0\u1ee3c hi\u1ec3u r\u00f5 h\u01a1n, m\u1edf ra con \u0111\u01b0\u1eddng cho c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb hi\u1ec7u qu\u1ea3 v\u00e0 nh\u1eafm m\u1ee5c ti\u00eau h\u01a1n.<\/p>\n

Trung t\u00e2m c\u1ee7a b\u01b0\u1edbc ti\u1ebfn n\u00e0y l\u00e0 ph\u00e1t hi\u1ec7n v\u00e0o n\u0103m 1994 v\u1ec1 leptin, m\u1ed9t lo\u1ea1i hormone do c\u00e1c t\u1ebf b\u00e0o m\u1ee1 s\u1ea3n sinh. Vai tr\u00f2 c\u1ee7a leptin \u0111\u01a1n gi\u1ea3n nh\u01b0ng quan tr\u1ecdng: th\u00f4ng b\u00e1o cho n\u00e3o b\u1ed9 v\u1ec1 m\u1ee9c \u0111\u1ed9 d\u1ef1 tr\u1eef n\u0103ng l\u01b0\u1ee3ng \u0111\u1ec3 \u0111i\u1ec1u ch\u1ec9nh c\u1ea3m gi\u00e1c th\u00e8m \u0103n v\u00e0 ti\u00eau hao n\u0103ng l\u01b0\u1ee3ng. \u1ede nh\u1eefng ng\u01b0\u1eddi b\u00e9o ph\u00ec, n\u1ed3ng \u0111\u1ed9 leptin th\u01b0\u1eddng cao, nh\u01b0ng n\u00e3o b\u1ed9 tr\u1edf n\u00ean k\u00e9m nh\u1ea1y c\u1ea3m v\u1edbi t\u00edn hi\u1ec7u c\u1ee7a n\u00f3, hi\u1ec7n t\u01b0\u1ee3ng n\u00e0y \u0111\u01b0\u1ee3c g\u1ecdi l\u00e0 kh\u00e1ng leptin. \u0110i\u1ec1u n\u00e0y l\u00e0m h\u1ea1n ch\u1ebf \u0111\u00e1ng k\u1ec3 hi\u1ec7u qu\u1ea3 c\u1ee7a c\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb d\u1ef1a tr\u00ean hormone n\u00e0y, m\u1eb7c d\u00f9 ban \u0111\u1ea7u c\u00f3 nhi\u1ec1u hy v\u1ecdng.<\/p>\n

Song song v\u1edbi \u0111\u00f3, m\u1ed9t lo\u1ea1i hormone kh\u00e1c, glucagon-like peptide-1 hay GLP-1, \u0111\u00e3 xu\u1ea5t hi\u1ec7n nh\u01b0 m\u1ed9t h\u01b0\u1edbng \u0111i \u0111\u1ea7y h\u1ee9a h\u1eb9n. GLP-1 \u0111\u01b0\u1ee3c ti\u1ebft ra b\u1edfi ru\u1ed9t sau khi \u0103n u\u1ed1ng, t\u00e1c \u0111\u1ed9ng tr\u00ean nhi\u1ec1u ph\u01b0\u01a1ng di\u1ec7n: gi\u1ea3m c\u1ea3m gi\u00e1c th\u00e8m \u0103n, l\u00e0m ch\u1eadm qu\u00e1 tr\u00ecnh l\u00e0m r\u1ed7ng d\u1ea1 d\u00e0y, k\u00edch th\u00edch ti\u1ebft insulin v\u00e0 c\u1ea3i thi\u1ec7n \u0111\u1ed9 nh\u1ea1y c\u1ea3m v\u1edbi insulin. Kh\u00f4ng gi\u1ed1ng nh\u01b0 leptin, c\u00e1c th\u1ee5 th\u1ec3 c\u1ee7a GLP-1 v\u1eabn gi\u1eef \u0111\u01b0\u1ee3c ch\u1ee9c n\u0103ng \u1edf ng\u01b0\u1eddi b\u00e9o ph\u00ec, khi\u1ebfn n\u00f3 tr\u1edf th\u00e0nh m\u1ee5c ti\u00eau \u0111i\u1ec1u tr\u1ecb l\u00fd t\u01b0\u1edfng.<\/p>\n

C\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb d\u1ef1a tr\u00ean ch\u1ea5t ch\u1ee7 v\u1eadn th\u1ee5 th\u1ec3 GLP-1, ch\u1eb3ng h\u1ea1n nh\u01b0 semaglutide hay liraglutide, \u0111\u00e3 c\u00e1ch m\u1ea1ng h\u00f3a vi\u1ec7c qu\u1ea3n l\u00fd b\u1ec7nh b\u00e9o ph\u00ec. Ch\u00fang gi\u00fap gi\u1ea3m c\u00e2n \u0111\u00e1ng k\u1ec3, th\u01b0\u1eddng tr\u00ean 10%, \u0111\u1ed3ng th\u1eddi c\u1ea3i thi\u1ec7n ki\u1ec3m so\u00e1t \u0111\u01b0\u1eddng huy\u1ebft v\u00e0 gi\u1ea3m nguy c\u01a1 tim m\u1ea1ch. C\u01a1 ch\u1ebf ho\u1ea1t \u0111\u1ed9ng c\u1ee7a ch\u00fang d\u1ef1a tr\u00ean vi\u1ec7c m\u00f4 ph\u1ecfng k\u00e9o d\u00e0i t\u00e1c d\u1ee5ng t\u1ef1 nhi\u00ean c\u1ee7a GLP-1, nh\u1edd c\u00e1c s\u1eeda \u0111\u1ed5i h\u00f3a h\u1ecdc gi\u00fap ch\u00fang ch\u1ed1ng l\u1ea1i s\u1ef1 ph\u00e2n h\u1ee7y nhanh ch\u00f3ng trong c\u01a1 th\u1ec3.<\/p>\n

Di truy\u1ec1n c\u0169ng \u0111\u00f3ng vai tr\u00f2 quan tr\u1ecdng trong xu h\u01b0\u1edbng b\u00e9o ph\u00ec. M\u1ed9t s\u1ed1 \u0111\u1ed9t bi\u1ebfn hi\u1ebfm, ch\u1eb3ng h\u1ea1n nh\u01b0 nh\u1eefng \u0111\u1ed9t bi\u1ebfn \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn gen leptin ho\u1eb7c th\u1ee5 th\u1ec3 c\u1ee7a n\u00f3, g\u00e2y ra b\u00e9o ph\u00ec nghi\u00eam tr\u1ecdng ngay t\u1eeb th\u1eddi th\u01a1 \u1ea5u. Th\u01b0\u1eddng xuy\u00ean h\u01a1n, \u0111\u00f3 l\u00e0 nh\u1eefng bi\u1ebfn th\u1ec3 gen nh\u1ecf, c\u00f3 m\u1eb7t trong h\u00e0ng tr\u0103m gen, t\u00edch l\u0169y l\u1ea1i v\u1edbi nhau \u0111\u1ec3 t\u0103ng nguy c\u01a1 m\u1eafc b\u1ec7nh. Trong s\u1ed1 \u0111\u00f3, gen FTO l\u00e0 m\u1ed9t trong nh\u1eefng gen c\u00f3 \u1ea3nh h\u01b0\u1edfng m\u1ea1nh m\u1ebd nh\u1ea5t \u0111\u1ebfn ch\u1ec9 s\u1ed1 kh\u1ed1i c\u01a1 th\u1ec3 (BMI). Nh\u1eefng xu h\u01b0\u1edbng di truy\u1ec1n n\u00e0y t\u01b0\u01a1ng t\u00e1c v\u1edbi m\u00f4i tr\u01b0\u1eddng: ch\u1ebf \u0111\u1ed9 \u0103n u\u1ed1ng gi\u00e0u dinh d\u01b0\u1ee1ng v\u00e0 l\u1ed1i s\u1ed1ng \u00edt v\u1eadn \u0111\u1ed9ng l\u00e0m t\u0103ng c\u01b0\u1eddng t\u00e1c \u0111\u1ed9ng c\u1ee7a ch\u00fang.<\/p>\n

C\u00e1c \u0111a h\u00ecnh, nh\u1eefng bi\u1ebfn th\u1ec3 t\u1ef1 nhi\u00ean trong ADN, c\u0169ng \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn ph\u1ea3n \u1ee9ng v\u1edbi \u0111i\u1ec1u tr\u1ecb. V\u00ed d\u1ee5, m\u1ed9t s\u1ed1 bi\u1ebfn th\u1ec3 c\u1ee7a gen th\u1ee5 th\u1ec3 GLP-1 l\u00e0m thay \u0111\u1ed5i hi\u1ec7u qu\u1ea3 c\u1ee7a c\u00e1c ch\u1ea5t ch\u1ee7 v\u1eadn, gi\u1ea3i th\u00edch t\u1ea1i sao m\u1ed9t s\u1ed1 b\u1ec7nh nh\u00e2n \u0111\u00e1p \u1ee9ng t\u1ed1t h\u01a1n nh\u1eefng ng\u01b0\u1eddi kh\u00e1c. Nh\u1eefng ph\u00e1t hi\u1ec7n n\u00e0y nh\u1ea5n m\u1ea1nh t\u1ea7m quan tr\u1ecdng c\u1ee7a y h\u1ecdc c\u00e1 nh\u00e2n h\u00f3a, n\u01a1i h\u1ed3 s\u01a1 di truy\u1ec1n c\u00f3 th\u1ec3 h\u01b0\u1edbng d\u1eabn l\u1ef1a ch\u1ecdn ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb ph\u00f9 h\u1ee3p nh\u1ea5t.<\/p>\n

S\u1ef1 t\u01b0\u01a1ng t\u00e1c gi\u1eefa leptin v\u00e0 GLP-1 l\u00e0 m\u1ed9t h\u01b0\u1edbng nghi\u00ean c\u1ee9u h\u1ea5p d\u1eabn kh\u00e1c. C\u00e1c nghi\u00ean c\u1ee9u cho th\u1ea5y GLP-1 c\u00f3 th\u1ec3 kh\u00f4i ph\u1ee5c m\u1ed9t ph\u1ea7n \u0111\u1ed9 nh\u1ea1y c\u1ea3m v\u1edbi leptin, \u0111\u1eb7c bi\u1ec7t l\u00e0 th\u00f4ng qua t\u00e1c \u0111\u1ed9ng l\u00ean h\u1ec7 vi sinh v\u1eadt \u0111\u01b0\u1eddng ru\u1ed9t. S\u1ef1 hi\u1ec7p \u0111\u1ed3ng n\u00e0y m\u1edf ra tri\u1ec3n v\u1ecdng cho c\u00e1c li\u1ec7u ph\u00e1p k\u1ebft h\u1ee3p, k\u1ebft h\u1ee3p c\u1ea3 hai hormone \u0111\u1ec3 t\u0103ng c\u01b0\u1eddng hi\u1ec7u qu\u1ea3. C\u00e1c ph\u00e2n t\u1eed nh\u01b0 tirzepatide, ho\u1ea1t h\u00f3a c\u1ea3 th\u1ee5 th\u1ec3 GLP-1 v\u00e0 GIP (m\u1ed9t hormone \u0111\u01b0\u1eddng ru\u1ed9t kh\u00e1c), \u0111\u00e3 ch\u1ee9ng minh hi\u1ec7u qu\u1ea3 v\u01b0\u1ee3t tr\u1ed9i so v\u1edbi c\u00e1c ph\u01b0\u01a1ng ph\u00e1p ch\u1ec9 nh\u1eafm m\u1ee5c ti\u00eau v\u00e0o GLP-1.<\/p>\n

Tuy nhi\u00ean, nh\u1eefng ti\u1ebfn b\u1ed9 trong \u0111i\u1ec1u tr\u1ecb n\u00e0y c\u0169ng \u0111i k\u00e8m v\u1edbi kh\u00f4ng \u00edt th\u00e1ch th\u1ee9c. C\u00e1c t\u00e1c d\u1ee5ng ph\u1ee5, ch\u1ee7 y\u1ebfu li\u00ean quan \u0111\u1ebfn ti\u00eau h\u00f3a nh\u01b0 bu\u1ed3n n\u00f4n ho\u1eb7c ti\u00eau ch\u1ea3y, c\u00f3 th\u1ec3 h\u1ea1n ch\u1ebf tu\u00e2n th\u1ee7 \u0111i\u1ec1u tr\u1ecb. Chi ph\u00ed cao c\u1ee7a c\u00e1c lo\u1ea1i thu\u1ed1c n\u00e0y c\u0169ng \u0111\u1eb7t ra v\u1ea5n \u0111\u1ec1 v\u1ec1 kh\u1ea3 n\u0103ng ti\u1ebfp c\u1eadn, l\u00e0m gia t\u0103ng b\u1ea5t b\u00ecnh \u0111\u1eb3ng trong ch\u0103m s\u00f3c s\u1ee9c kh\u1ecfe. Ngo\u00e0i ra, ng\u1eebng \u0111i\u1ec1u tr\u1ecb th\u01b0\u1eddng d\u1eabn \u0111\u1ebfn t\u0103ng c\u00e2n tr\u1edf l\u1ea1i, nh\u1ea5n m\u1ea1nh s\u1ef1 c\u1ea7n thi\u1ebft c\u1ee7a m\u1ed9t c\u00e1ch ti\u1ebfp c\u1eadn l\u00e2u d\u00e0i.<\/p>\n

Do \u0111\u00f3, b\u00e9o ph\u00ec kh\u00f4ng c\u00f2n \u0111\u01b0\u1ee3c xem l\u00e0 v\u1ea5n \u0111\u1ec1 \u0111\u01a1n thu\u1ea7n v\u1ec1 \u00fd ch\u00ed, m\u00e0 l\u00e0 m\u1ed9t c\u0103n b\u1ec7nh \u0111a y\u1ebfu t\u1ed1, n\u01a1i sinh h\u1ecdc, di truy\u1ec1n v\u00e0 l\u1ed1i s\u1ed1ng \u0111an xen l\u1eabn nhau. Nh\u1eefng ti\u1ebfn b\u1ed9 g\u1ea7n \u0111\u00e2y trong vi\u1ec7c hi\u1ec3u bi\u1ebft v\u1ec1 c\u00e1c hormone nh\u01b0 leptin v\u00e0 GLP-1, c\u0169ng nh\u01b0 trong vi\u1ec7c x\u00e1c \u0111\u1ecbnh c\u00e1c y\u1ebfu t\u1ed1 di truy\u1ec1n, \u0111ang thay \u0111\u1ed5i c\u00e1ch th\u1ee9c ti\u1ebfp c\u1eadn c\u0103n b\u1ec7nh n\u00e0y. C\u00e1c ph\u01b0\u01a1ng ph\u00e1p \u0111i\u1ec1u tr\u1ecb hi\u1ec7n nay, m\u1eb7c d\u00f9 \u0111\u1ea7y h\u1ee9a h\u1eb9n, v\u1eabn c\u1ea7n ti\u1ebfp t\u1ee5c ph\u00e1t tri\u1ec3n \u0111\u1ec3 tr\u1edf n\u00ean d\u1ec5 ti\u1ebfp c\u1eadn h\u01a1n v\u1edbi t\u1ea5t c\u1ea3 m\u1ecdi ng\u01b0\u1eddi v\u00e0 b\u1ec1n v\u1eefng trong d\u00e0i h\u1ea1n.<\/p>\n

“`<\/p>\n

\n

Sources du site<\/h2>\n

Source officielle de l\u2019\u00e9tude<\/h3>\n

DOI\u00a0:<\/strong> https:\/\/doi.org\/10.1007\/s13353-026-01084-5<\/a><\/p>\n

Titre\u00a0:<\/strong> Unravelling obesity: from leptin to glucagon-like peptide-1 receptor agonists<\/p>\n

Revue : <\/strong> Journal of Applied Genetics<\/p>\n

\u00c9diteur : <\/strong> Springer Science and Business Media LLC<\/p>\n

Auteurs : <\/strong> Taiwo Oluwafemi Idowu; Agata Chmurzynska<\/p>\n","protected":false},"excerpt":{"rendered":"

“`html B\u00e9o ph\u00ec ti\u1ebft l\u1ed9 b\u00ed m\u1eadt gi\u1eefa gen v\u00e0 hormone B\u00e9o ph\u00ec hi\u1ec7n \u1ea3nh h\u01b0\u1edfng \u0111\u1ebfn g\u1ea7n 30% d\u00e2n s\u1ed1 th\u1ebf gi\u1edbi, con s\u1ed1 \u0111\u00e3 t\u0103ng g\u1ea5p ba l\u1ea7n k\u1ec3 t\u1eeb n\u0103m 1975. L\u00e2u nay, b\u1ec7nh n\u00e0y th\u01b0\u1eddng \u0111\u01b0\u1ee3c xem l\u00e0 s\u1ef1 m\u1ea5t c\u00e2n b\u1eb1ng \u0111\u01a1n thu\u1ea7n gi\u1eefa l\u01b0\u1ee3ng calo n\u1ea1p v\u00e0o v\u00e0 ti\u00eau… Continue reading B\u00e9o ph\u00ec ti\u1ebft l\u1ed9 b\u00ed m\u1eadt gi\u1eefa gen v\u00e0 hormone<\/span><\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,2],"tags":[],"class_list":["post-23","post","type-post","status-publish","format-standard","hentry","category-moi-truong","category-suc-khoe","entry"],"_links":{"self":[{"href":"https:\/\/biologistjournal.com\/vi\/wp-json\/wp\/v2\/posts\/23","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/biologistjournal.com\/vi\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/biologistjournal.com\/vi\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/biologistjournal.com\/vi\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/biologistjournal.com\/vi\/wp-json\/wp\/v2\/comments?post=23"}],"version-history":[{"count":1,"href":"https:\/\/biologistjournal.com\/vi\/wp-json\/wp\/v2\/posts\/23\/revisions"}],"predecessor-version":[{"id":24,"href":"https:\/\/biologistjournal.com\/vi\/wp-json\/wp\/v2\/posts\/23\/revisions\/24"}],"wp:attachment":[{"href":"https:\/\/biologistjournal.com\/vi\/wp-json\/wp\/v2\/media?parent=23"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/biologistjournal.com\/vi\/wp-json\/wp\/v2\/categories?post=23"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/biologistjournal.com\/vi\/wp-json\/wp\/v2\/tags?post=23"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}